ea0005p131 | Endocrine Tumours and Neoplasia | BES2003
Mozid A
, Tringali G
, Forsling M
, Hendricks M
, Ajodha S
, Edwards R
, Navarra P
, Grossman A
, Korbonits M
Ghrelin is a brain-gut peptide originally identified in the stomach. It binds to and stimulates the growth hormone secretagogue receptor type 1a (GHS-R). The presence of ghrelin in hypothalamic tissue was studied. It has been previously established that neither the synthetic GHSs, nor the endogenous hormone ghrelin, is specific for GH stimulation: they generally also stimulate the HPA axis as well as prolactin release. Since there is no direct stimulatory effect on ACTH releas...